ROS in cancer therapy: the bright side of the moon

B Perillo, M Di Donato, A Pezone, E Di Zazzo… - … & molecular medicine, 2020 - nature.com
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. It is now well accepted that moderate …

Mechanisms of nanoparticle‐induced oxidative stress and toxicity

A Manke, L Wang, Y Rojanasakul - BioMed research …, 2013 - Wiley Online Library
The rapidly emerging field of nanotechnology has offered innovative discoveries in the
medical, industrial, and consumer sectors. The unique physicochemical and electrical …

Free radicals, metals and antioxidants in oxidative stress-induced cancer

M Valko, CJB Rhodes, J Moncol, MM Izakovic… - Chemico-biological …, 2006 - Elsevier
Oxygen-free radicals, more generally known as reactive oxygen species (ROS) along with
reactive nitrogen species (RNS) are well recognised for playing a dual role as both …

Oxidative stress and cell signalling

G Poli, G Leonarduzzi, F Biasi… - Current medicinal …, 2004 - ingentaconnect.com
An increasing body of evidence from animal models, human specimens and cell lines points
to reactive oxygen species as likely involved in the pathways, which convey both …

Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase

JP McClung, CA Roneker, W Mu… - Proceedings of the …, 2004 - National Acad Sciences
Insulin resistance, a hallmark of type 2 diabetes, is associated with oxidative stress.
However, the role of reactive oxygen species or specific antioxidant enzymes in its …

Vascular NADPH oxidases: molecular mechanisms of activation

RP Brandes, J Kreuzer - Cardiovascular research, 2005 - academic.oup.com
Oxygen-derived free radicals are thought to contribute to the initiation and progression of
cardiovascular disease via several different mechanisms, such as consumption of nitric …

Heavy metals, islet function and diabetes development

YW Chen, CY Yang, CF Huang, DZ Hung, YM Leung… - Islets, 2009 - Taylor & Francis
Heavy metals have been known to possess many adverse health effects for a long time.
Uncontrolled industrialization breaks out heavy metal pollution in the world. Heavy metal …

Reactive oxygen species-dependent signaling regulates cancer

F Weinberg, NS Chandel - Cellular and molecular life sciences, 2009 - Springer
Historically, it has been assumed that oxidative stress contributes to tumor initiation and
progression solely by inducing genomic instability. Recent studies indicate that reactive …

Long-term intermittent hypoxia in mice: protracted hypersomnolence with oxidative injury to sleep-wake brain regions

SC Veasey, CW Davis, P Fenik, G Zhan, YJ Hsu… - Sleep, 2004 - academic.oup.com
Abstract Study Objectives: This study was designed to test the hypothesis that long-term
intermittent hypoxia (LTIH), modeling the hypoxia-reoxygenation events of sleep apnea …

Adaptation to oxidative stress, chemoresistance, and cell survival

M Landriscina, F Maddalena, G Laudiero… - Antioxidants & redox …, 2009 - liebertpub.com
The discovery of some additional properties and functions of reactive oxygen species (ROS),
beyond their toxic effects, provides a novel scenario for the molecular basis and cell …