Chemical and biophysical signatures of the protein corona in nanomedicine

J Ren, N Andrikopoulos, K Velonia… - Journal of the …, 2022 - ACS Publications
An inconvenient hurdle in the practice of nanomedicine is the protein corona, a spontaneous
collection of biomolecular species by nanoparticles in living systems. The protein corona is …

Recent advances in understanding the protein corona of nanoparticles and in the formulation of “stealthy” nanomaterials

R Rampado, S Crotti, P Caliceti, S Pucciarelli… - … in bioengineering and …, 2020 - frontiersin.org
In the last decades, the staggering progress in nanotechnology brought around a wide and
heterogeneous range of nanoparticle-based platforms for the diagnosis and treatment of …

Bioinspired shielding strategies for nanoparticle drug delivery applications

NM Gulati, PL Stewart, NF Steinmetz - Molecular pharmaceutics, 2018 - ACS Publications
Nanoparticle delivery systems offer advantages over free drugs, in that they increase
solubility and biocompatibility. Nanoparticles can deliver a high payload of therapeutic …

[HTML][HTML] Engineering nanoparticles to overcome immunological barriers for enhanced drug delivery

T Malachowski, A Hassel - Engineered Regeneration, 2020 - Elsevier
Nanotechnology has recently gained traction in the medical field as a method of targeted
delivery and timed release of therapeutic drugs. As interest in this field grows, design …

Delivery of siRNA therapeutics using cowpea chlorotic mottle virus-like particles

P Lam, NF Steinmetz - Biomaterials science, 2019 - pubs.rsc.org
While highly promising in medicine, gene therapy requires delivery agents to protect and
target nucleic acid therapeutics. We developed a plant viral siRNA delivery platform making …

Developing protein-based nanoparticles as versatile delivery systems for cancer therapy and imaging

F Sandra, NU Khaliq, A Sunna, A Care - Nanomaterials, 2019 - mdpi.com
In recent years, it has become apparent that cancer nanomedicine's reliance on synthetic
nanoparticles as drug delivery systems has resulted in limited clinical outcomes. This is …

The pharmacology of plant virus nanoparticles

CI Nkanga, NF Steinmetz - Virology, 2021 - Elsevier
The application of nanoparticles for medical purposes has made enormous strides in
providing new solutions to health problems. The observation that plant virus-based …

Multifunctional plant virus nanoparticles in the next generation of cancer immunotherapies

M Shahgolzari, H Dianat-Moghadam… - Seminars in cancer biology, 2022 - Elsevier
Plant virus nanoparticles (PVNPs) have inherent immune stimulatory ability, and have been
investigated as immune adjuvants to stimulate an anti-tumor immune response. The …

Knowledge gaps in immune response and immunotherapy involving nanomaterials: Databases and artificial intelligence for material design

R Feng, F Yu, J Xu, X Hu - Biomaterials, 2021 - Elsevier
Exploring the interactions between the immune system and nanomaterials (NMs) is critical
for designing effective and safe NMs, but large knowledge gaps remain to be filled prior to …

Plant-derived nanoparticles and plant virus nanoparticles: Bioactivity, health management, and delivery potential

C Liu, Y Yu, L Fang, J Wang, C Sun, H Li… - Critical Reviews in …, 2023 - Taylor & Francis
Natural plants have acquired an increasing attention in biomedical research. Recent studies
have revealed that plant-derived nanoparticles (PDNPs), which are nano-sized membrane …