Protamines are the major nuclear sperm proteins. The human sperm nucleus contains two
types of protamine: protamine 1 (P1) encoded by a single-copy gene and the family of …

During the elongating spermatid stage of spermiogenesis, human sperm chromatin
undergoes a complex transition in which histones are extensively replaced by protamines in …

Male fertility throughout life hinges on the successful production of motile sperm, a
developmental process that involves three coordinated transitions: mitosis, meiosis, and …

Aim: Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal
genetic information, and normal sperm chromatin structure is important for sperm fertilizing …

During male germ cell postmeiotic maturation, dramatic chromatin reorganization occurs,
which is driven by completely unknown mechanisms. For the first time, we describe a …

In mammalian fertilization, the paternal genome is delivered to the secondary oocyte by
sperm with protamine compacted DNA, while the maternal genome is arrested in meiotic …

Conventional dogma presumes that protamine-mediated DNA compaction in sperm is
achieved by electrostatic interactions between DNA and the arginine-rich core of …

Histone replacement by transition proteins (TPs) and protamines (Prms) constitutes an
essential step for the successful production of functional male gametes, yet nothing is known …

Spermiogenesis refers to the process by which postmeiotic spermatids differentiate into
elongated spermatids and eventually spermatozoa. During spermiogenesis, round …

BACKGROUND: A significant relationship exists between an abnormally high sperm
protamine-1 (P1)/protamine-2 (P2) ratio and male infertility. In this study we investigate …