Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …

Iron dysregulation has been implicated in multiple neurodegenerative diseases, including
Parkinson's disease (PD). Iron-loaded microglia are frequently found in affected brain …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing
coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to …

Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for
degradation. Here we consider its roles in neuronal health and disease. We review …

Autophagosome biogenesis involves de novo formation of a membrane that elongates to
sequester cytoplasmic cargo and closes to form a double-membrane vesicle (an …

Autophagy is the process of cellular self-eating by a double-membrane organelle, the
autophagosome. A range of signaling processes converge on two protein complexes to …

Across all branches of the immune system, the process of autophagy is fundamentally
important in cellular development, function and homeostasis. Strikingly, this evolutionarily …

Autophagy is a conserved intracellular pathway that delivers cytoplasmic contents to
lysosomes for degradation via double-membrane autophagosomes. Autophagy substrates …

Autolysosomes contain components from autophagosomes and lysosomes. The contents
inside the autolysosomal lumen are degraded during autophagy, while the fate of …