Voltage-gated sodium channels (VGSCs) participate in generating and spreading action
potentials in electrically excited cells such as neurons and muscle fibers. Abnormal …

In addition to its prominent role as an energetic substrate in the brain, lactate is emerging as
a signaling molecule capable of controlling neuronal excitability. The finding that the lactate …

Benzylparaben (BzP) is a potential endocrine disruptor; however, its antioxidant defense,
lipotoxicity and underlying mechanism of BzP in aquatic organisms are unknown. This study …

This study investigated the estrogen-like effects and mechanism of action most commonly
used parabens: methyl-(MeP), ethyl-(EtP), propyl-(PrP) and butylparaben (BuP) in human …

Background and Purpose Dysregulation of dopaminergic transmission combined with
transient hypofunction of N‐methyl‐d‐aspartate receptors (NMDARs) is a key mechanism …

Introduction: Third-generation antiepileptic drugs have seemingly failed to improve the
global figures of seizure control and can still be regarded as symptomatic treatments …

Organophosphorus (OP) compounds are deadly chemicals that exert their intoxicating
effects through the irreversible inhibition of acetylcholinesterase (AChE). In addition to an …

Hippocampal pyramidal neuronal activity has been previously studied using conventional
patch clamp in isolated cells and brain slices. We here introduce the loose patch clamping …

Propylparaben (PrP) is a widely used preservative that is constantly detected in aquatic
environments and poses a potential threat to aquatic ecosystems. In the present work, adult …

Propylparaben (PPB) induces cardioprotection after ischemia–reperfusion injury by
inhibiting voltage-dependent Na+ channels. The present study focuses on investigating …