Ischemic stroke generates an immune response that contributes to neuronal loss as well as
tissue repair. This is a complex process involving a range of cell types and effector …

Immunity and inflammation are key elements of the pathobiology of stroke, a devastating
illness second only to cardiac ischemia as a cause of death worldwide. The immune system …

The immune response after stroke is known to play a major role in ischemic brain
pathobiology. The inflammatory signals released by immune mediators activated by brain …

atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and
collateral formation, stroke, and heart failure. In this review, we discuss in detail the …

NADPH oxidases are a family of enzymes that generate reactive oxygen species (ROS). The
NOX1 (NADPH oxidase 1) and NOX2 oxidases are the major sources of ROS in the artery …

Perinatal hypoxia-ischemia remains the primary cause of acute neonatal brain injury,
leading to a high mortality rate and long-term neurological deficits, such as behavioral …

Brain infarction causes tissue death by ischemia due to occlusion of the cerebral vessels
and recent work has shown that post stroke inflammation contributes significantly to the …

Stroke is a frequent cause of long-term disability and death worldwide. Ischemic stroke is
more commonly encountered compared to hemorrhagic stroke, and leads to tissue death by …

Inflammation plays a critical role in mediating brain injury induced by neonatal hypoxic
ischemic encephalopathy (HIE). The mechanisms underlying inflammatory responses to …

Hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of morbidity and
mortality in neonates. Because of high concentrations of sensitive immature cells, metal …