In this review we focus on the idea of establishing connections between the mechanical
properties of DNA–ligand complexes and the physical chemistry of DNA–ligand interactions …

Cell-free DNA (cfDNA) is a liquid biopsy marker that can carry signatures (ie, mutations)
associated with certain pathological conditions. Therefore, the extraction of cfDNA from a …

DNA carries important genetic instructions and plays vital roles in regulating biological
activities in living cells. Proteins such as transcription factors binds to DNA to regulate the …

DNA condensation is a ubiquitous phenomenon in biology, yet the physical basis for it has
remained elusive. Here, we have explored the mechanism of DNA condensation through the …

Abstract Iron (II) and Ru (II) half-sandwich compounds encompass some promising pre-
clinical anticancer agents whose efficacy may be tuned by structural modification of the …

Optically active liquid–crystalline dispersions (LCD) of nucleic acids, obtained by polymer-
and salt-induced (psi-) condensation, eg, by mixing of aqueous saline solutions of low …

By using optical tweezers with an adjustable trap stiffness, we have performed systematic
single molecule stretching experiments with two types of DNA–intercalator complexes, in …

Background DNA bridging promoted by the H-NS protein, combined with the compaction
induced by cellular crowding, plays a major role in the structuring of the E. coli genome …

Platinum-containing molecules are widely used as anticancer drugs. These molecules exert
cytotoxic effects by binding to DNA through various mechanisms. The binding between DNA …

We present a new study on the interaction of the DNA molecule with the surfactant
dodecyltrimethylammonium bromide (DTAB), performed mainly with optical tweezers. Single …