Chemical and physical properties of the environment control cell proliferation, differentiation,
or apoptosis in the long term. However, to be able to move and migrate through a complex …

The linkage of cells to their microenvironment is mediated by a series of bonds that
dynamically engage and disengage, in what has been conceptualized as the molecular …

Mechanical cues from the extracellular matrix (ECM) regulate various cellular processes via
distinct mechanotransduction pathways. In breast cancer, increased ECM stiffness promotes …

Morphogenesis, tumor formation, and wound healing are regulated by tissue rigidity. Focal
adhesion behavior is locally regulated by stiffness; however, how cells globally adapt …

It is increasingly clear that mechanotransduction pathways play important roles in regulating
fundamental cellular functions. Of the basic mechanical functions, the determination of …

The receptor tyrosine kinase (RTK) AXL has been intrinsically linked to epithelial–
mesenchymal transition (EMT) and promoting cell survival, anoikis resistance, invasion, and …

Over the past decade, researchers have highlighted the importance of mechanical cues of
the metastatic niche such as matrix stiffness, topography, mechanical stresses, and …

Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein,
which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a …

Cancer metastasis requires the invasion of tumor cells into the stroma and the directed
migration of tumor cells through the stroma toward the vasculature and lymphatics where …

A common feature of cancer cells is the alteration of kinases and biochemical signalling
pathways enabling transformed growth on soft matrices, whereas cytoskeletal protein …