The contribution of the sphingosine 1-phosphate signaling pathway to chronic kidney diseases: recent findings and new perspectives
S Schwalm, R Manaila, A Oftring, L Schaefer… - … -European Journal of …, 2024 - Springer
Chronic kidney disease (CKD) is a multifactorial condition with diverse etiologies, such as
diabetes mellitus, hypertension, and genetic disorders, often culminating in end-stage renal …
diabetes mellitus, hypertension, and genetic disorders, often culminating in end-stage renal …
Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate
Summary Sphingosine-1-phosphate (S1P) is an important signaling sphingolipid that
regulates the immune system, angiogenesis, auditory function, and epithelial and …
regulates the immune system, angiogenesis, auditory function, and epithelial and …
Mitochondrial oxidative damage reprograms lipid metabolism of renal tubular epithelial cells in the diabetic kidney
Y Hou, E Tan, H Shi, X Ren, X Wan, W Wu… - Cellular and Molecular …, 2024 - Springer
The functional and structural changes in the proximal tubule play an important role in the
occurrence and development of diabetic kidney disease (DKD). Diabetes-induced metabolic …
occurrence and development of diabetic kidney disease (DKD). Diabetes-induced metabolic …
Microbiota-derived imidazole propionate inhibits type 2 diabetic skin wound healing by targeting SPNS2-mediated S1P transport
S Zheng, H Wang, J Han, X Dai, Y Lv, T Sun, H Liu - Iscience, 2023 - cell.com
Imidazole propionate (ImP) is a recently discovered metabolite of T2DM-related gut
microbiota. The effect of ImP on T2DM wound healing has not been studied yet. In this …
microbiota. The effect of ImP on T2DM wound healing has not been studied yet. In this …
Blocking sphingosine 1-phosphate receptor 1 with modulators reduces immune cells infiltration and alleviates endometriosis in mice
F Zhang, M Peng, X Zheng, X Wang, X Liu… - Reproductive …, 2023 - Elsevier
Research question Do sphingosine 1-phosphate (S1P) modulators have therapeutic effects
on endometriosis in mice and, if they do, which receptor is responsible for these effects …
on endometriosis in mice and, if they do, which receptor is responsible for these effects …