Rodent models of rheumatoid arthritis (RA) have been used over decades to study the
immunopathogenesis of the disease and to explore intervention strategies. Nevertheless …

Background Despite the conventional cancer therapeutic, cancer treatment remains a
medical challenge due to neoplasm metastasis and cancer recurrence; therefore, new …

Background: During a developmental process, embryos employ varying tactics to remove
unwanted cells. Using a procedure analogous to some of the embryonic cells, we generated …

Background: Advanced breast cancer frequently metastasizes to bone, but inhibiting tumor
progression in chemotherapy may occasionally enhance tumorigenesis. Here, we employed …

The remarkable success of targeted immunotherapies is revolutionizing cancer treatment.
However, tumor heterogeneity and low immunogenicity, in addition to several tumor …

Simple Summary Osteoclasts are bone-resorbing cells and, together with bone-forming
osteoblasts, they are responsible for maintaining healthy bones. When cancer cells invade …

Despite the advance in medications in the past decade, aggressive breast cancer such as
triple-negative breast cancer is difficult to treat. Here, we examined a counter-intuitive …

Cancer immunotherapies may be limited by their failure to target cancer stem cells (CSCs).
We previously described an approach to target these cells using a dendritic cell (DC) …

Cancer stem cells (CSCs) are responsible for therapeutic resistance and recurrence in
colorectal cancer. Despite advances in immunotherapy, the inability to specifically eradicate …

Breast cancer (BC) is one of the main causes of cancer-related death worldwide. The
heterogenicity of breast tumors and the presence of tumor resistance, metastasis, and …