Copper-based compounds are promising entities for target-specific next-generation
anticancer and NSAIDS therapeutics. In lieu of this, benzimidazole scaffold plays an …

This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …

One of the strategies in the search for safe and effective analgesic drugs is the design of
multitarget analgesics. Such compounds are intended to have high affinity and activity at …

Objective: Oxytocin (OT) is synthesized within the paraventricular nucleus and supraoptic
nucleus of the hypothalamus. In addition to its role in uterine contraction, OT plays an …

Mounting evidence indicates that the neuropeptide FF (NPFF) system is involved in the side
effects of opioid usage, including antinociceptive tolerance, hyperalgesia, abuse …

We previously reported that a multifunctional opioid/neuropeptide FF receptor agonist, DN-9,
achieved peripherally restricted analgesia with reduced side effects. To develop stable and …

Our previous study reported the multifunctional agonist for opioid and neuropeptide FF
receptors DN-9, along with its cyclic peptide analogues c [D-Cys2, Cys5]-DN-9 and c [D …

The endogenous neuropeptide FF (NPFF) and its two cognate G protein-coupled receptors,
Neuropeptide FF Receptors 1 and 2 (NPFFR1 and NPFFR2), represent a relatively new …

Background and Purpose Considerable effort has recently been directed at developing
multifunctional opioid drugs to minimize the unwanted side effects of opioid analgesics. We …

A convenient and functional-group-tolerant organocatalytic asymmetric 1, 4-addition of
azlactones and dehydroalanine is disclosed. The reaction is used for the first synthesis of …