Emerging roles of spliceosome in cancer and immunity
Precursor messenger RNA (pre-mRNA) splicing is catalyzed by an intricate
ribonucleoprotein complex called the spliceosome. Although the spliceosome is considered …
ribonucleoprotein complex called the spliceosome. Although the spliceosome is considered …
Regulation and function of R-loops at repetitive elements
A Gambelli, A Ferrando, C Boncristiani, S Schoeftner - Biochimie, 2023 - Elsevier
R-loops are atypical, three-stranded nucleic acid structures that contain a stretch of RNA:
DNA hybrids and an unpaired, single stranded DNA loop. R-loops are physiological relevant …
DNA hybrids and an unpaired, single stranded DNA loop. R-loops are physiological relevant …
SRSF1 haploinsufficiency is responsible for a syndromic developmental disorder associated with intellectual disability
E Bogaert, A Garde, T Gautier, K Rooney… - The American Journal of …, 2023 - cell.com
SRSF1 (also known as ASF/SF2) is a non-small nuclear ribonucleoprotein (non-snRNP) that
belongs to the arginine/serine (R/S) domain family. It recognizes and binds to mRNA …
belongs to the arginine/serine (R/S) domain family. It recognizes and binds to mRNA …
Insights into established and emerging roles of SR protein family in plants and animals
Splicing of pre‐mRNA is an essential part of eukaryotic gene expression. Serine‐/arginine‐
rich (SR) proteins are highly conserved RNA‐binding proteins present in all metazoans and …
rich (SR) proteins are highly conserved RNA‐binding proteins present in all metazoans and …
Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function
F Haward, MM Maslon, PL Yeyati, N Bellora… - Elife, 2021 - elifesciences.org
Shuttling RNA-binding proteins coordinate nuclear and cytoplasmic steps of gene
expression. The SR family proteins regulate RNA splicing in the nucleus and a subset of …
expression. The SR family proteins regulate RNA splicing in the nucleus and a subset of …
Alternative splicing of pre-mRNA in the control of immune activity
Z Su, D Huang - Genes, 2021 - mdpi.com
The human immune response is a complex process that responds to numerous exogenous
antigens in preventing infection by microorganisms, as well as to endogenous components …
antigens in preventing infection by microorganisms, as well as to endogenous components …
The chaperone protein p32 stabilizes HIV-1 Tat and strengthens the p-TEFb/RNAPII/TAR complex promoting HIV transcription elongation
HIV gene expression is modulated by the combinatorial activity of the HIV transcriptional
activator, Tat, host transcription factors, and chromatin remodeling complexes. To identify …
activator, Tat, host transcription factors, and chromatin remodeling complexes. To identify …
Drug delivery approaches for HuR-targeted therapy for lung cancer
Lung cancer (LC) is often diagnosed at an advanced stage and conventional treatments for
disease management have limitations associated with them. Novel therapeutic targets are …
disease management have limitations associated with them. Novel therapeutic targets are …
Comprehensive analysis of circRNA-miRNA-mRNA regulatory network and novel potential biomarkers in acute myocardial infarction
J Wu, C Li, Z Lei, H Cai, Y Hu, Y Zhu… - Frontiers in …, 2022 - frontiersin.org
Background Circular RNA (circRNA) plays an important role in the regulation of gene
expression and the occurrence of human diseases. However, studies on the role of circRNA …
expression and the occurrence of human diseases. However, studies on the role of circRNA …
Unveiling dysregulated lncRNAs and networks in non-syndromic cleft lip with or without cleft palate pathogenesis
C Wu, H Liu, Z Zhan, X Zhang, M Zhang, J You… - Scientific Reports, 2024 - nature.com
Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a common congenital facial
malformation with a complex, incompletely understood origin. Long noncoding RNAs …
malformation with a complex, incompletely understood origin. Long noncoding RNAs …