Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS,
which can be compared across CNS regions, patients, and centres. In patients with multiple …

Hypomyelinating leukodystrophies constitute a subset of genetic white matter disorders
characterized by a primary lack of myelin deposition. Most patients with severe …

Myelin repair is an unrealized therapeutic goal in the treatment of multiple sclerosis (MS).
Uncertainty remains about the optimal techniques for assessing therapeutic efficacy and …

Myelin water imaging is a quantitative neuroimaging technique that provides the myelin
water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular …

The ratio of T1-weighted/T2-weighted magnetic resonance images (T1w/T2w MRI) has been
successfully applied at the cortical level since 2011 and is now one of the most used myelin …

Myelin is the protective sheath wrapped around axons, consisting of a phospholipid bilayer
with water between the wraps. The measurement of damage to the myelin sheaths, the …

The in-vivo profiling of iron and myelin across cortical depths and underlying white matter
has important implications for advancing knowledge about their roles in brain development …

Purpose The multi‐exponential T2 decay of the MRI signal from cerebral white matter can be
separated into short T2 components related to myelin water and long T2 components related …

Purpose To estimate for each distinct fiber population within voxels containing multiple brain
tissue types. Methods A diffusion‐correlation experiment was carried out in an in vivo human …

Purpose Based on a deep learning neural network (NN) algorithm, a super fast and easy to
implement data analysis method was proposed for myelin water imaging (MWI) to calculate …