Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications
Q Zhong, X Xiao, Y Qiu, Z Xu, C Chen, B Chong… - MedComm, 2023 - Wiley Online Library
Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …
Mechanisms of primordial follicle activation and new pregnancy opportunity for premature ovarian failure patients
T Zhang, M He, J Zhang, Y Tong, T Chen… - Frontiers in …, 2023 - frontiersin.org
Primordial follicles are the starting point of follicular development and the basic functional
unit of female reproduction. Primordial follicles are formed around birth, and most of the …
unit of female reproduction. Primordial follicles are formed around birth, and most of the …
Origin and evolution of RAS membrane targeting
A García-España, MR Philips - Oncogene, 2023 - nature.com
Abstract KRAS, HRAS and NRAS proto-oncogenes belong to a family of 40 highly
homologous genes, which in turn are a subset of a superfamily of> 160 genes encoding …
homologous genes, which in turn are a subset of a superfamily of> 160 genes encoding …
Lipidation of small GTPase Cdc42 as regulator of its physiological and pathophysiological functions
A Wirth, E Ponimaskin - Frontiers in Physiology, 2023 - frontiersin.org
The protein cell division cycle 42 (Cdc42) is a small GTPase of the Rho family regulating a
plethora of physiological functions in a tissue, cell and subcellular-specific manner via …
plethora of physiological functions in a tissue, cell and subcellular-specific manner via …
An isoform-specific function of Cdc42 in regulating mammalian Exo70 during axon formation
P Ravindran, AW Püschel - Life Science Alliance, 2023 - life-science-alliance.org
The highly conserved GTPase Cdc42 is an essential regulator of cell polarity and promotes
exocytosis through the exocyst complex in budding yeast and Drosophila. In mammals, this …
exocytosis through the exocyst complex in budding yeast and Drosophila. In mammals, this …
Polar targeting of proteins–a green perspective
EM Pukhovaya, JJ Ramalho… - Journal of Cell …, 2024 - journals.biologists.com
Cell polarity–the asymmetric distribution of molecules and cell structures within the cell–is a
feature that almost all cells possess. Even though the cytoskeleton and other intracellular …
feature that almost all cells possess. Even though the cytoskeleton and other intracellular …
[HTML][HTML] Regulation of anxiety-like behaviors by S-palmitoylation and S-nitrosylation in basolateral amygdala
ZC Shen, JM Liu, JY Zheng, MD Li, D Tian… - Biomedicine & …, 2023 - Elsevier
Protein posttranslational modification regulates synaptic protein stability, sorting and
trafficking, and is involved in emotional disorders. Yet the molecular mechanisms regulating …
trafficking, and is involved in emotional disorders. Yet the molecular mechanisms regulating …
Thyroid hormone T3 induces Fyn modification and modulates palmitoyltransferase gene expression through αvβ3 integrin receptor in PC12 cells during hypoxia
E Kvergelidze, T Barbakadze, J Bátor… - Translational …, 2024 - degruyter.com
Thyroid hormones (THs) are essential in neuronal and glial cell development and
differentiation, synaptogenesis, and myelin sheath formation. In addition to nuclear …
differentiation, synaptogenesis, and myelin sheath formation. In addition to nuclear …
[HTML][HTML] Origin and evolution of RAS oncoprotein membrane targeting
A García-España, MR Philips - Research Square, 2023 - ncbi.nlm.nih.gov
Abstract KRAS, HRAS and NRAS oncogenes belong to a family of 40 highly homologous
genes, which in turn are a subset of a superfamily of> 160 genes encoding small GTPases …
genes, which in turn are a subset of a superfamily of> 160 genes encoding small GTPases …