CRISPR-Cas9 and Cre recombinase, two tools extensively used for genome interrogation,
have catalyzed key breakthroughs in our understanding of complex biological processes …

Improving the efficiency and precision of gene editing systems is of utmost importance for
modern molecular biology and genetic engineering. Of particular interest is the design of …

The design of controllable and precise RNA-targeted CRISPR/Cas9 (Clustered Regularly
Interspaced Short Palindromic Repeats) systems is an important problem of modern …

Objective: The development of CRISPR/Cas-based gene-editing systems having a higher
efficacy and specificity, and capable of changing activity in response to light irradiation is an …

Here, we proposed a new approach to engineering a photoactivatable CRISPR/Cas9 gene-
editing system. The novel nanoCRISPR/Cas9 system is based on the use of auxiliary …

Objective: The development of controllable gene editing systems based on the CRISPR/Cas
technology is a problem of immediate interest in modern molecular biology and genetic …

Photoregulated systems are interesting and prospective instruments to affect gene
expression. An approach to the synthesis of photoregulated siRNA has been proposed for …

The development of controllable gene editing systems on the base of CRISPR/Cas is an
actually problem of modern molecular biology and genetic enginery. Interesting variant of …

The development of gene editing systems on the base of CRISPR/Cas having higher
efficacy, specificity, and possibility of their activity regulation by light irradiation is actually …

Предложен подход к доставке направляющей РНК для системы CRISPR/Cas9 в клетки,
основанный на использовании дополнительного олигонуклеотида, комплементарного …