Cell cycle progression is a tightly regulated process by which DNA replicates and cell
reproduces. The major driving force underlying cell cycle progression is the sequential …

Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …

To ensure its duplication, chromosomal DNA must be precisely duplicated in each cell cycle,
with no sections left unreplicated, and no sections replicated more than once. Eukaryotic …

Eukaryotic DNA replication is regulated to ensure all chromosomes replicate once and only
once per cell cycle. Replication begins at many origins scattered along each chromosome …

In eukaryotic cells, prereplication complexes (pre-RCs) are assembled on chromatin in the
G1 phase, rendering origins of DNA replication competent to initiate DNA synthesis. When …

One of the fundamental challenges facing the cell is to accurately copy its genetic material to
daughter cells. When this process goes awry, genomic instability ensues in which genetic …

The eukaryotic cell cycle is a fundamental evolutionarily conserved process that regulates
cell division from simple unicellular organisms, such as yeast, through to higher multicellular …

Mitosis is accompanied by dramatic changes in chromatin organization and nuclear
architecture. Transcription halts globally and most sequence-specific transcription factors …

Initiation and completion of DNA replication defines the beginning and ending of S phase of
the cell cycle. Successful progression through S phase requires that replication be properly …

The initiation of DNA replication represents a committing step to cell proliferation.
Appropriate replication onset depends on multiprotein complexes that help properly …