▪ Abstract The transcription factor NF-κB has attracted widespread attention among
researchers in many fields based on the following: its unusual and rapid regulation, the wide …

▪ Abstract The transcription factor NF-κB, more than a decade after its discovery, remains an
exciting and active area of study. The involvement of NF-κB in the expression of numerous …

Transcription of endothelial‐leukocyte adhesion molecule‐1 (E‐selectin or ELAM‐1),
vascular cell adhesion molecule‐1 (VCAM‐1), and intercellular adhesion molecule‐l (ICAM …

Tumor necrosis factor α (TNF-α) signaling gives rise to a number of events, including
activation of transcription factor NF-κB and programmed cell death (apoptosis). Previous …

The transcription factor NF-kappa B is sequestered in the cytoplasm by the inhibitor protein I
kappa B alpha. Extracellular inducers of NF-kappa B activate signal transduction pathways …

▪ Abstract The Toll-Dorsal pathway in Drosophila and the interleukin-1 receptor (IL-1R)-NF-
κB pathway in mammals are homologous signal transduction pathways that mediate several …

Mutations in the Proteolytic Enzyme Calpain 3 Cause Limb-Girdle Muscular Dystrophy Type
2A Page 1 Cell, Vol. 81, 27-40, April 7, 1995, Copyright © 1995 by Cell Press Mutations in …

Ced-4 and Apaf-1 belong to a major class of apoptosis regulators that contain caspase-
recruitment (CARD) and nucleotide-binding oligomerization domains. Nod1, a protein with …

Signal-induced activation of the transcription factor NF-κB requires specific phosphorylation
of the inhibitor IκBα and its subsequent proteolytic degradation. Phosphorylation of serine …

Phosphorylation of inhibitor of kappa B (IκB) proteins is an important step in the activation of
the transcription nuclear factor kappa B (NF-κB) and requires two IκB kinases, IKK1 (IKKα) …