Simple Summary Overexpression of ABCB1 has been identified in a wide range of multidrug-
resistant cancers. ABCB1 can become upregulated in many ways, and understanding these …

Cancer is a complex group of diseases that constitute the second largest cause of mortality
worldwide. The development of new drugs for treating this disease is a long and costly …

Tuberculosis treatment requires months-long combination chemotherapy with multiple
drugs, with shorter treatments leading to relapses. A major impediment to shortening …

The strong barrier function of the blood–brain barrier (BBB) protects the central nervous
system (CNS) from xenobiotic substances, while the expression of selective transporters …

Marine bivalve molluscs are one of the primary seafood for consumers. Inhabiting
terrigenous pollutant-convergent coastal areas and feeding through seawater filtration …

Membrane proteins play critical roles in disease and in the disposition of many
pharmaceuticals. A prime example is P-glycoprotein (Pgp) which moves a diverse range of …

Molecular dynamics (MD) simulations have been used extensively to study P-glycoprotein
(P-gp), a flexible multidrug transporter that is a key player in the development of multidrug …

Cancer has become a leading cause of mortality due to non-communicable diseases after
cardiovascular disease worldwide and is increasing day by day at a daunting pace …

Colon cancer is a serious malignant type of cancer in the world. Acquisition of multi-drug
resistance (MDR) during chemotherapy is still a controversial challenge during cancer …

The lipopolysaccharide, a microbial toxin, is one of the major causative agents of sepsis. P-
gp expression and its functions are altered during inflammation. LPS has been known to …