The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …

Pancreatic islet transplantation has become an established approach to β-cell replacement
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …

Insulin-producing β cells created from human pluripotent stem cells have potential as a
therapy for insulin-dependent diabetes, but human pluripotent stem cell-derived islets (SC …

Islet transplantation can restore endogenous β-cell function to subjects with type 1 diabetes.
Sixty-five patients received an islet transplant in Edmonton as of 1 November 2004. Their …

ContextIslet allografts from 2 to 4 donors can reverse type 1 diabetes. However, for islet
transplants to become a widespread clinical reality, diabetes reversal must be achieved with …

Although pancreas transplantation is increasingly being performed in an effort to provide
type 1 diabetic patients with the possibility of an insulin-injection–free existence, islet …

Type 2 diabetic subjects manifest both disordered insulin action and abnormalities in their
pancreatic islet cells. Whether the latter represents a primary defect or is a consequence of …

Transplantation (CIT) Consortium jointly developed and implemented a harmonized process
for manufacture of the allogeneic Purified Human Pancreatic Islet (PHPI) product evaluated …

Following the success obtained with transplantation of fresh human islets under steroid‐free
immunosuppression, this trial evaluated the transplantation of islets that had undergone a …

Recent advances in clinical protocols have improved the outcomes of pancreatic islet
transplantation (PIT), yet PIT recipients typically require pancreatic islet grafts derived from …