ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies
AC Raulin, SV Doss, ZA Trottier, TC Ikezu, G Bu… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
The glymphatic system: a novel component of fundamental neurobiology
LM Hablitz, M Nedergaard - Journal of Neuroscience, 2021 - Soc Neuroscience
Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …
ApoE isoform–and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy
Tau-mediated neurodegeneration is a hallmark of Alzheimer's disease. Primary tauopathies
are characterized by pathological tau accumulation and neuronal and synaptic loss …
are characterized by pathological tau accumulation and neuronal and synaptic loss …
Current understanding of the Alzheimer's disease-associated microbiome and therapeutic strategies
D Seo, DM Holtzman - Experimental & molecular medicine, 2024 - nature.com
Alzheimer's disease (AD) is a fatal progressive neurodegenerative disease. Despite
tremendous research efforts to understand this complex disease, the exact pathophysiology …
tremendous research efforts to understand this complex disease, the exact pathophysiology …
Genetic and environmental factors in Alzheimer's and Parkinson's diseases and promising therapeutic intervention via fecal microbiota transplantation
H Wang, F Yang, S Zhang, R Xin, Y Sun - npj Parkinson's Disease, 2021 - nature.com
Neurodegenerative diseases are characterized by neuronal impairment and loss of function,
and with the major shared histopathological hallmarks of misfolding and aggregation of …
and with the major shared histopathological hallmarks of misfolding and aggregation of …
APOE Alleles and Diet in Brain Aging and Alzheimer's Disease
HN Yassine, CE Finch - Frontiers in aging neuroscience, 2020 - frontiersin.org
The APOE gene alleles modify human aging and the response to the diet at many levels
with diverse pleotropic effects from gut to brain. To understand the interactions of APOE …
with diverse pleotropic effects from gut to brain. To understand the interactions of APOE …
The microbiota–microglia axis in central nervous system disorders
The innate immune system in the central nervous system (CNS) is mainly represented by
specialized tissue‐resident macrophages, called microglia. In the past years, various …
specialized tissue‐resident macrophages, called microglia. In the past years, various …
Alzheimer's disease and diabetes: Role of diet, microbiota and inflammation in preclinical models
MJ Carranza-Naval, M Vargas-Soria… - Biomolecules, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia. Epidemiological studies
show the association between AD and type 2 diabetes (T2DM), although the mechanisms …
show the association between AD and type 2 diabetes (T2DM), although the mechanisms …
Diet, microbiota and brain health: unraveling the network intersecting metabolism and neurodegeneration
F Gentile, PE Doneddu, N Riva… - International journal of …, 2020 - mdpi.com
Increasing evidence gives support for the idea that extra-neuronal factors may affect brain
physiology and its predisposition to neurodegenerative diseases. Epidemiological and …
physiology and its predisposition to neurodegenerative diseases. Epidemiological and …
[HTML][HTML] Gut dysbiosis and age-related neurological diseases in females
JM Korf, BP Ganesh, LD McCullough - Neurobiology of disease, 2022 - Elsevier
Historically, females have been underrepresented in biological research. With increased
interest in the gut microbiome and the gut-brain axis, it is important for researchers to pursue …
interest in the gut microbiome and the gut-brain axis, it is important for researchers to pursue …