Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC)
with a poor prognosis. Current treatment options are limited to surgery, adjuvant …

Cholesterol metabolism produces essential membrane components as well as metabolites
with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell …

Cholesterol is an essential structural component of membranes that contributes to
membrane integrity and fluidity. Cholesterol homeostasis plays a critical role in the …

Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h
rhythms in cellular and bodily functions across nearly all living species. These internal clock …

Cholesterol is a multifaceted metabolite that is known to modulate processes in cancer,
atherosclerosis, and autoimmunity. A common denominator between these diseases …

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

Tumor cells reprogram their metabolism to produce specialized metabolites that both fuel
their own growth and license tumor immune evasion. However, the relationships between …

Triple-negative breast cancer (TNBC) is a heterogeneous disease characterized by poor
response to standard therapies and therefore unfavorable clinical outcomes. Better …

Copy number alterations (CNAs) are pivotal genetic events in triple-negative breast cancer
(TNBC). Here, our integrated copy number and transcriptome analysis of 302 TNBC patients …

The widespread clinical use of statins has contributed to significant reductions of
cardiovascular morbidity and mortality. Increasing preclinical and epidemiological …