Research with animal models of obsessive-compulsive disorder (OCD) shows the
following:(1) Optogenetic studies in mice provide evidence for a plausible cause-effect …

This review evaluates current knowledge about obsessive-compulsive disorder (OCD), with
the goal of providing a roadmap for future directions in research on the …

The strength of goal-oriented behaviors is regulated by midbrain dopamine neurons.
Dysfunctions of dopaminergic circuits are observed in drug addiction and obsessive …

OCD has lagged behind other psychiatric illnesses in the identification of molecular
treatment targets, due in part to a lack of significant findings in genome-wide association …

Abstract Obsessive-compulsive disorder (OCD), a highly prevalent and debilitating disorder,
is incompletely understood in terms of underpinning behavioural, psychological, and neural …

This study investigated whether the serotonin 5-HT 1A receptor agonist 8-hydroxy-2-(di-n-
propylamino) tetralin (8-OH-DPAT) can induce compulsive checking in a large open field, as …

Abstract Obsessive-compulsive disorder (OCD), a highly prevalent and debilitating disorder,
is incompletely understood in terms of underpinning behavioural, psychological, and neural …

Dopamine from the ventral tegmental area and glutamate from several brain nuclei
converge in the nucleus accumbens (NAc) to drive motivated behaviors. Repeated …

The quinpirole sensitization model of obsessive‐compulsive disorder was used to
investigate the functional role that brain regions implicated in a neuroanatomical circuit of …

Quinpirole-sensitized rats were tested on a discrete-trials 40-s peak-interval procedure
using lever pressing as the instrumental response. Although there was no evidence of …