In addition to inducing lethal DNA damage in tumor and stromal cells, radiation can alter the
interactions of tumor cells with their microenvironment. Recent technological advances in …

Dependency on tumor oxygenation is one of the major features of radiation therapy and this
has led many radiation biologists and oncologists to focus on tumor hypoxia. The first …

Purpose No standard therapy exists for metastatic urothelial cancer (UC) that has
progressed after initial chemotherapy. This trial was designed to assess the efficacy and …

Sunitinib is an orally available small-molecule multikinase inhibitor. This agent potently
inhibits the vascular endothelial growth factor receptor, platelet-derived growth factor …

Structural and functional abnormalities in tumor blood vessels impact the delivery of oxygen
and nutrients to solid tumors, resulting in chronic and cycling hypoxia. Although chronically …

Pancreatic cancer is the fourth leading cause of cancer-related deaths in the USA. The high
mortality rate is partly due to lack of effective treatments. This review summarizes the …

Increasing experimental and clinical evidence has revealed a critical role for myeloid cells in
the development and progression of cancer. The ability of monocytes and macrophages to …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal types of cancer due to the
relatively late diagnosis and the limited therapeutic options. Current treatment regimens …

OBJECTIVE The object of this retrospective study was to investigate the impact of targeted
therapies on overall survival (OS), distant intracranial failure, local failure, and radiation …

Ionizing radiation (IR) is an important cancer treatment approach. However, radioresistance
eventually occurs, resulting in poor outcomes in patients with cancer. Radioresistance is …