The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

Cytosolic delivery of bioactive agents has exhibited great potential to cure undruggable
targets and diseases. Because biological cell membranes are a natural barrier for living …

Uncontrolled inflammation is responsible for acute and chronic diseases in the lung.
Regulating expression of pro-inflammatory genes in pulmonary tissue using small interfering …

Although subcellular targeting can enhance the therapeutic performance of most drugs,
such targeting requires appropriate carrier-based delivery that can bypass …

Although efficient cell nucleus delivery of exogenous materials can greatly improve their
biochemical activity, this is strictly restricted by cellular uptake and intracellular trafficking …

The efficient delivery of biologics into cells provide unique opportunities to modulate
intracellular targets not druggable by conventional small molecules. The supercharged …

Current intracellular protein delivery strategies face the challenge of endosomal entrapment
and consequent degradation of protein cargo. Methods to efficiently deliver proteins directly …

Vaccination through cellular transfection of nucleotide-based vaccines is a powerful
approach to combatting disease. Plasmid DNA (pDNA) vaccines are particularly promising …

Amidst the rapid growth of protein therapeutics as a drug class, there is an increased focus
on designing systems to effectively deliver proteins to target organs. Quantitative monitoring …

Protein biologics are powerful therapeutic agents with diverse inhibitory and enzymatic
functions. However, their clinical use has been limited to extracellular applications due to …