Dengue virus (DENV) infects approximately 390 million persons every year in more than
100 countries. Reports of neurological complications are more frequently. The objective of …

Neuroinflammation (inflammation in brain) has been known to play an important role in the
development of dengue virus disease. Recently, studies from both clinical and experimental …

Current design of Zika virus (ZIKV) vaccine mainly considered envelope (E) as the major
target antigen. Non-structural protein NS1 was seldom considered. Herein, we generated …

Dengue, a mosquito-borne zoonotic disease, is the most common vector-borne disease in
tropical and subtropical areas. In this study, we aim to demonstrate biological evidence of …

Dengue fever is caused by any of the four known dengue virus serotypes (DENV1 to
DENV4) that affect millions of people worldwide, causing a significant number of deaths …

Generating neutralizing antibodies have been considered a prerequisite to control dengue
virus (DENV) infection. However, T lymphocytes have also been shown to be important in a …

Background The clinical presentation of dengue is classified by the World Health
Organization into dengue without warning signs, dengue with warning signs and severe …

Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a
significant burden of morbidity and mortality. Disease models are necessary to understand …

Dengue nonstructural protein 1 (NS1) is a multi-functional glycoprotein with essential
functions both in viral replication and modulation of host innate immune responses. NS1 has …

Encephalitis has been described worldwide as a severe complication in patients infected by
dengue virus. Reactive oxygen species (ROS) production is a key mechanism involved in …