Peroxisome proliferator-activated receptor gamma (PPARγ) has been implicated in the
pathology of numerous diseases involving diabetes, stroke, cancer, or obesity. It is …

Andrographis paniculata (Burm. F) Nees, generally known as “king of bitters,” is an
herbaceous plant in the family Acanthaceae. In China, India, Thailand, and Malaysia, this …

Abstract Introduction Mesenchymal stem cells (MSCs) are adult, multipotent, stem cells with
immunomodulatory properties. The mechanisms involved in the capacity of MSCs to inhibit …

Since their discovery by Steinman and Cohn in 1973, dendritic cells (DCs) have become
increasingly recognized for their crucial role as regulators of innate and adaptive immunity …

Autoimmune diseases affect roughly 5-10% of the total population, with women affected
more than men. The standard treatment for autoimmune or autoinflammatory diseases had …

Andrographis paniculata has long been part of the traditional herbal medicine system in
Asia and in Scandinavia. Andrographolide was isolated as a major bioactive constituent of …

Background: The blood–brain barrier acts as a highly regulated interface; its dysfunction
may exacerbate, and perhaps initiate, neurological and neuropsychiatric disorders …

Neuroinflammation is involved in several neurodegenerative disorders and emerging
evidence indicates that it constitutes a critical process that is required for the progression of …

Botanicals have attracted much attention in the field of anti-inflammatory due to their good
pharmacological activity and efficacy. Andrographis paniculata is a natural plant ingredient …

Naturally occurring CD4+ CD25high forkhead box protein 3 (FOXP3)+ regulatory T cells
(nTregs) are key mediators of immunity, which orchestrate and maintain tolerance to self and …