Ultrasound technologies for imaging and modulating neural activity

C Rabut, S Yoo, RC Hurt, Z Jin, H Li, H Guo, B Ling… - Neuron, 2020 - cell.com
Visualizing and perturbing neural activity on a brain-wide scale in model animals and
humans is a major goal of neuroscience technology development. Established electrical and …

[HTML][HTML] Recent ultrasound advancements for the manipulation of nanobiomaterials and nanoformulations for drug delivery

SS Low, CN Lim, M Yew, WS Chai, LE Low… - Ultrasonics …, 2021 - Elsevier
Recent advances in ultrasound (US) have shown its great potential in biomedical
applications as diagnostic and therapeutic tools. The coupling of US-assisted drug delivery …

Functional ultrasound imaging: a new imaging modality for neuroscience

T Deffieux, C Demené, M Tanter - Neuroscience, 2021 - Elsevier
Ultrasound sensitivity to slow blood flow motion gained two orders of magnitude in the last
decade thanks to the advent of ultrafast ultrasound imaging at thousands of frames per …

Ultrasensitive ultrasound imaging of gene expression with signal unmixing

DP Sawyer, A Bar-Zion, A Farhadi, S Shivaei, B Ling… - Nature …, 2021 - nature.com
Acoustic reporter genes (ARGs) that encode air-filled gas vesicles enable ultrasound-based
imaging of gene expression in genetically modified bacteria and mammalian cells …

Functional ultrasound neuroimaging

G Montaldo, A Urban, E Macé - Annual Review of Neuroscience, 2022 - annualreviews.org
Functional ultrasound (fUS) is a neuroimaging method that uses ultrasound to track changes
in cerebral blood volume as an indirect readout of neuronal activity at high spatiotemporal …

Truly tiny acoustic biomolecules for ultrasound imaging and therapy

B Ling, B Gungoren, Y Yao, P Dutka… - Advanced …, 2024 - Wiley Online Library
Nanotechnology offers significant advantages for medical imaging and therapy, including
enhanced contrast and precision targeting. However, integrating these benefits into …

Single-trial decoding of movement intentions using functional ultrasound neuroimaging

SL Norman, D Maresca, VN Christopoulos, WS Griggs… - Neuron, 2021 - cell.com
New technologies are key to understanding the dynamic activity of neural circuits and
systems in the brain. Here, we show that a minimally invasive approach based on …

Biomolecular ultrasound imaging of phagolysosomal function

B Ling, J Lee, D Maresca, A Lee-Gosselin… - ACS …, 2020 - ACS Publications
Phagocytic clearance and lysosomal processing of pathogens and debris are essential
functions of the innate immune system. However, the assessment of these functions in vivo …

Gas Vesicle–Blood Interactions Enhance Ultrasound Imaging Contrast

B Ling, JH Ko, B Stordy, Y Zhang, TF Didden… - Nano Letters, 2023 - ACS Publications
Gas vesicles (GVs) are genetically encoded, air-filled protein nanostructures of broad
interest for biomedical research and clinical applications, acting as imaging and therapeutic …

Sonogenetics for Monitoring and Modulating Biomolecular Function by Ultrasound

J Hahmann, A Ishaqat, T Lammers… - Angewandte Chemie …, 2024 - Wiley Online Library
Ultrasound technology, synergistically harnessed with genetic engineering and chemistry
concepts, has started to open the gateway to the remarkable realm of sonogenetics—a …