Maintenance of Na+ and K+ gradients across the cell plasma membrane is an essential
process for mammalian cell survival. An enzyme responsible for this process, sodium …

Skeletal muscle contains one of the largest and the most dynamic pools of Na, K-ATPase
(NKA) in the body. Under resting conditions, NKA in skeletal muscle operates at only a …

Na, K-ATPase is highly sensitive to changes in the redox state, and yet the mechanisms of
its redox sensitivity remain unclear. We have explored the possible involvement of S …

In this brief review we discuss some aspects of the Na+ pump and its roles in mediating the
effects of ouabain and endogenous ouabain (EO): i) in regulating the cytosolic Ca 2+ …

The cardiac phosphoprotein phospholemman (PLM) regulates the cardiac sodium pump,
activating the pump when phosphorylated and inhibiting it when palmitoylated. Protein …

Reversible protein S-glutathiolation has emerged as an important mechanism of post-
translational modification. Under basal conditions several proteins remain adducted to …

Control over the Na, K-ATPase function plays a central role in adaptation of the organisms to
hypoxic and anoxic conditions. As the enzyme itself does not possess O 2 binding sites its …

Cardiometabolic diseases (CMD) are a direct consequence of modern living and contribute
to the development of multisystem diseases such as cardiovascular diseases and diabetes …

Na/K-ATPase has been extensively studied for its ion pumping function, but, in the past
several decades, has been identified as a scaffolding and signaling protein. Initially it was …

Key points Training with blood flow restriction (BFR) is a well‐recognized strategy for
promoting muscle hypertrophy and strength. However, its potential to enhance muscle …