Missing value imputation for gene expression data: computational techniques to recover missing data from available information

AWC Liew, NF Law, H Yan - Briefings in bioinformatics, 2011 - academic.oup.com
Microarray gene expression data generally suffers from missing value problem due to a
variety of experimental reasons. Since the missing data points can adversely affect …

Dealing with missing values in large-scale studies: microarray data imputation and beyond

T Aittokallio - Briefings in bioinformatics, 2010 - academic.oup.com
High-throughput biotechnologies, such as gene expression microarrays or mass-
spectrometry-based proteomic assays, suffer from frequent missing values due to various …

Non-targeted UHPLC-MS metabolomic data processing methods: a comparative investigation of normalisation, missing value imputation, transformation and scaling

R Di Guida, J Engel, JW Allwood, RJM Weber… - Metabolomics, 2016 - Springer
Introduction The generic metabolomics data processing workflow is constructed with a serial
set of processes including peak picking, quality assurance, normalisation, missing value …

Missing data imputation using statistical and machine learning methods in a real breast cancer problem

JM Jerez, I Molina, PJ García-Laencina, E Alba… - Artificial intelligence in …, 2010 - Elsevier
OBJECTIVES: Missing data imputation is an important task in cases where it is crucial to use
all available data and not discard records with missing values. This work evaluates the …

Missing values in mass spectrometry based metabolomics: an undervalued step in the data processing pipeline

O Hrydziuszko, MR Viant - Metabolomics, 2012 - Springer
Missing values in mass spectrometry metabolomic datasets occur widely and can originate
from a number of sources, including for both technical and biological reasons. Currently …

Improved methods for the imputation of missing data by nearest neighbor methods

G Tutz, S Ramzan - Computational Statistics & Data Analysis, 2015 - Elsevier
Missing data raise problems in almost all fields of quantitative research. A useful
nonparametric procedure is the nearest neighbor imputation method. Improved versions of …

An assessment of recently published gene expression data analyses: reporting experimental design and statistical factors

P Jafari, F Azuaje - BMC Medical Informatics and Decision Making, 2006 - Springer
Background The analysis of large-scale gene expression data is a fundamental approach to
functional genomics and the identification of potential drug targets. Results derived from …

Which missing value imputation method to use in expression profiles: a comparative study and two selection schemes

GN Brock, JR Shaffer, RE Blakesley, MJ Lotz… - BMC …, 2008 - Springer
Background Gene expression data frequently contain missing values, however, most down-
stream analyses for microarray experiments require complete data. In the literature many …

Improving cluster-based missing value estimation of DNA microarray data

LP Brás, JC Menezes - Biomolecular engineering, 2007 - Elsevier
We present a modification of the weighted K-nearest neighbours imputation method
(KNNimpute) for missing values (MVs) estimation in microarray data based on the reuse of …

Treatment and reporting of item-level missing data in social science research

A Berchtold - International Journal of Social Research …, 2019 - Taylor & Francis
Most quantitative studies in the social sciences suffer from missing data. However, despite
the large availability of documents and software to treat such data, it appears that many …