The dopaminergic system plays important roles in neuromodulation, such as motor control,
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …

Sleep is regulated by a homeostatic and a circadian process. Together these two processes
determine most aspects of sleep and related variables like sleepiness and alertness. The …

For many years, researchers have suggested that abnormalities in circadian rhythms may
underlie the development of mood disorders such as bipolar disorder (BPD), major …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

The primary mammalian circadian clock resides in the suprachiasmatic nucleus (SCN), a
recipient of dense retinohypothalamic innervation. In its most basic form, the circadian …

Endogenous circadian clocks are robust regulators of physiology and behavior.
Synchronization or entrainment of biological clocks to environmental time is adaptive and …

Sleep is a vital and evolutionarily conserved process, critical to daily functioning and
homeostatic balance. Losing sleep is inherently stressful and leads to numerous detrimental …

A significant subset of both major depressive disorder and bipolar disorder patients rapidly
(within 24 hours) and robustly improves with the chronotherapeutic intervention of sleep …

Sleep has a regulatory role in maintaining metabolic homeostasis and cellular functions.
Inadequate sleep time and sleep disorders have become more prevalent in the modern …

Pharmacological and genetic tools targeting the 5-hydroxytryptamine (5-HT) 7 receptor in
preclinical animal models have implicated this receptor in diverse (patho) physiological …