Abstract α-Thalassemia is an inherited, autosomal recessive, disorder characterized by a
microcytic hypochromic anemia. It is one of the most common monogenic gene disorders in …

Thalassemia is one of the most common monogenic disorders in the world. 1 It is estimated
that nearly 70,000 children with various forms of thalassemia are born each year. 2 …

Alpha-thalassemia is one of the most common hemoglobin genetic abnormalities and is
caused by the reduced or absent production of the alpha globin chains. Alpha-thalassemia …

The thalassemias, together with sickle cell anemia and its variants, are the world's most
common form of inherited anemia, and in economically undeveloped countries, they still …

The globin gene disorders including the thalassemias are among the most common human
genetic diseases with more than 300,000 severely affected individuals born throughout the …

Abstract β-Thalassemia is one of the most common inherited anemias, with no effective cure
for most patients. The pathophysiology reflects an imbalance between α-and β-globin chains …

Thalassemia syndromes are among the commonest monogenic disorders and represent a
substantial health burden worldwide. Here the authors have described globin genes …

Over the past three decades, a vast amount of new information has been uncovered
describing how the globin genes are regulated. This knowledge has provided significant …

β-Thalassaemia is caused by over 300 mutations in and around the β-globin gene that lead
to impaired synthesis of β-globin. The expression of α-globin continues normally, resulting in …

Over the last three decades, studies of the α-and β-globin genes clusters have led to
elucidation of the general principles of mammalian gene regulation, such as RNA stability …