It is from the discovery of leptin and the central nervous system as a regulator of bone
remodeling that the presence of autonomic nerves within the skeleton transitioned from a …

The skeleton is no longer seen as a static, isolated, and mostly structural organ. Over the last
two decades, a more complete picture of the multiple functions of the skeleton has emerged …

The lifespan of people with severe mental illness (SMI) is shorter compared to the general
population. This excess mortality is mainly due to physical illness. We report prevalence …

Background Selective serotonin reuptake inhibitors (SSRIs) are a widely used class of
antidepressants that block the serotonin transporter. Osteoblasts and osteocytes express …

Puberty is the period of development when sexual, reproductive maturity is reached. The
span of puberty covers the approximate ages of 9–15 in girls and 10–16 in boys. Why is this …

Major depression is associated with low bone mass and increased incidence of osteoporotic
fractures. However, causality between depression and bone loss has not been established …

Osteoporosis is a major public health threat. Multiple studies have reported an association
between depression and low bone mineral density, but a causal link between these two …

Major depressive disorder has been associated with low bone mineral density. The strength
of this association, however, varies greatly among studies; the direction of the causative link …

Background An increased prevalence of low bone mineral density (BMD) has been reported
in patients with major depressive disorder (MDD), mostly women. Methods Study recruitment …

It has been shown that antidepressants would have a direct action on bone metabolism and
would be associated with increased fracture risk. Results from this large meta-analysis show …