RNA processing plays a central role in accurately transmitting genetic information into
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …

BACKGROUND The eukaryotic genome is hierarchically organized in the cell nucleus into
DNA loops, chromatin domains, compartments, and, ultimately, chromosomes. Many of the …

Forces generated by the cytoskeleton can be transmitted to the nucleus and chromatin via
physical links on the nuclear envelope and the lamin meshwork. Although the role of these …

Cells integrate physicochemical signals on the nanoscale from the local microenvironment,
resulting in altered functional nuclear landscape and gene expression. These alterations …

Chromosomes within eukaryotic cell nuclei at interphase are not positioned at random, since
gene-rich chromosomes are predominantly found towards the interior of the cell nucleus …

The human genome is highly dynamic across all scales. At the gene level, chromatin is
persistently remodeled and rearranged during active processes such as transcription …

In this review we describe major contributions of light and electron microscopic approaches
to the present understanding of functional nuclear architecture. The large gap of knowledge …

Efficient and reproducible construction of signaling and sorting complexes, both on the
surface and within the living cell, is contingent on local regulation of biochemical reactions …

Inspite of being embedded in a dense meshwork of nuclear chromatin, gene loci and large
nuclear components are highly dynamic at C. To understand this apparent unfettered …

The dynamic organization of chromatin inside the cell nucleus plays a key role in gene
regulation and genome replication, as well as maintaining genome integrity. Although the …