Contribution of the gut microbiome to drug disposition, pharmacokinetic and pharmacodynamic variability
SM Tsunoda, C Gonzales, AK Jarmusch… - Clinical …, 2021 - Springer
The trillions of microbes that make up the gut microbiome are an important contributor to
health and disease. With respect to xenobiotics, particularly orally administered compounds …
health and disease. With respect to xenobiotics, particularly orally administered compounds …
Inhibition of Cancer Development by Natural Plant Polyphenols: Molecular Mechanisms
A Lyubitelev, V Studitsky - International Journal of Molecular Sciences, 2023 - mdpi.com
Malignant tumors remain one of the main sources of morbidity and mortality around the
world. A chemotherapeutic approach to cancer treatment poses a multitude of challenges …
world. A chemotherapeutic approach to cancer treatment poses a multitude of challenges …
[HTML][HTML] Interaction of luteolin, naringenin, and their sulfate and glucuronide conjugates with human serum albumin, cytochrome P450 (CYP2C9, CYP2C19, and …
H Kaci, S Bodnárová, E Fliszár-Nyúl, B Lemli… - Biomedicine & …, 2023 - Elsevier
Luteolin and naringenin are flavonoids found in various foods/beverages and present in
certain dietary supplements. After a high intake of these flavonoids, their sulfate and …
certain dietary supplements. After a high intake of these flavonoids, their sulfate and …
[HTML][HTML] Interactions of resveratrol and its metabolites (resveratrol-3-sulfate, resveratrol-3-glucuronide, and dihydroresveratrol) with serum albumin, cytochrome P450 …
Resveratrol (RES) is a widely-known natural polyphenol which is also contained by several
dietary supplements. Large doses of RES can result in high micromolar levels of its sulfate …
dietary supplements. Large doses of RES can result in high micromolar levels of its sulfate …
Effects of chrysin and its major conjugated metabolites chrysin-7-sulfate and chrysin-7-glucuronide on cytochrome P450 enzymes and on OATP, P-gp, BCRP, and …
V Mohos, E Fliszár-Nyúl, O Ungvári, É Bakos… - Drug Metabolism and …, 2020 - ASPET
Chrysin is an abundant flavonoid in nature, and it is also contained by several dietary
supplements. Chrysin is highly biotransformed in the body, during which conjugated …
supplements. Chrysin is highly biotransformed in the body, during which conjugated …
Testing serum albumins and cyclodextrins as potential binders of the mycotoxin metabolites alternariol-3-sulfate, alternariol-9-monomethylether and alternariol-9 …
Alternaria mycotoxins, including alternariol (AOH), alternariol-9-monomethylether (AME),
and their masked/modified derivatives (eg, sulfates or glycosides), are common food …
and their masked/modified derivatives (eg, sulfates or glycosides), are common food …
Interaction of Fumonisin B1, N-Palmitoyl-Fumonisin B1, 5-O-Palmitoyl-Fumonisin B1, and Fumonisin B4 Mycotoxins with Human Serum Albumin and Their Toxic …
Fumonisins are frequent food contaminants. The high exposure to fumonisins can cause
harmful effects in humans and animals. Fumonisin B1 (FB1) is the most typical member of …
harmful effects in humans and animals. Fumonisin B1 (FB1) is the most typical member of …
[HTML][HTML] Application of omics technology to investigate the mechanism underlying the role of San Hua Tang in regulating microglia polarization and blood-brain barrier …
S Luo, Y Chen, R Zhao, D Ma, Y Zhao, Y Zhang… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacology relevance San Hua Tang (SHT) was first mentioned in the
book" The Collection of Plain Questions about Pathogenesis, Qi, and Life." SHT has the …
book" The Collection of Plain Questions about Pathogenesis, Qi, and Life." SHT has the …
[HTML][HTML] Extraction of mycotoxin alternariol from red wine and from tomato juice with beta-cyclodextrin bead polymer
Alternariol (AOH) is a mycotoxin which occurs in wine and tomato products as contaminant.
Cyclodextrins (CDs) are ring-shaped glucose oligomers. CD polymers seem to be suitable …
Cyclodextrins (CDs) are ring-shaped glucose oligomers. CD polymers seem to be suitable …
Interactions of mycotoxin alternariol with cytochrome p450 enzymes and oatp transporters
Alternariol (AOH) is an emerging mycotoxin produced by Alternaria strains. The acute
toxicity of the mycotoxin is low; however, chronic exposure to AOH may result in the …
toxicity of the mycotoxin is low; however, chronic exposure to AOH may result in the …