Mechanisms of alternative pre-messenger RNA splicing
DL Black - Annual review of biochemistry, 2003 - annualreviews.org
▪ Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher
eukaryotes. Variability in splicing patterns is a major source of protein diversity from the …
eukaryotes. Variability in splicing patterns is a major source of protein diversity from the …
Tropomyosin-based regulation of the actin cytoskeleton in time and space
Tropomyosins are rodlike coiled coil dimers that form continuous polymers along the major
groove of most actin filaments. In striated muscle, tropomyosin regulates the actin-myosin …
groove of most actin filaments. In striated muscle, tropomyosin regulates the actin-myosin …
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
MG Spillantini, JR Murrell, M Goedert… - Proceedings of the …, 1998 - National Acad Sciences
Familial multiple system tauopathy with presenile dementia (MSTD) is a neurodegenerative
disease with an abundant filamentous tau protein pathology. It belongs to the group of …
disease with an abundant filamentous tau protein pathology. It belongs to the group of …
Role of RNA structure in regulating pre-mRNA splicing
MB Warf, JA Berglund - Trends in biochemical sciences, 2010 - cell.com
Pre-mRNA splicing involves removing non-coding introns from RNA transcripts. It is carried
out by the spliceosome, along with other auxiliary factors. In general, research in splicing …
out by the spliceosome, along with other auxiliary factors. In general, research in splicing …
Influence of RNA secondary structure on the pre-mRNA splicing process
E Buratti, FE Baralle - Molecular and cellular biology, 2004 - Taylor & Francis
Pre-mRNA splicing in eukaryotes requires joining together the nucleotides of the various
mRNA-coding regions (exons) after recognizing them from the normally vastly superior …
mRNA-coding regions (exons) after recognizing them from the normally vastly superior …
5′ splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10
A Grover, H Houlden, M Baker, J Adamson… - Journal of Biological …, 1999 - ASBMB
Missense and splice site mutations in the microtubule-associated protein tau gene were
recently found associated with fronto-temporal dementia and parkinsonism linked to …
recently found associated with fronto-temporal dementia and parkinsonism linked to …
Modulating role of RNA structure in alternative splicing of a critical exon in the spinal muscular atrophy genes
Humans have two nearly identical copies of the survival motor neuron (SMN) gene, SMN1
and SMN2. Homozygous loss of SMN1 causes spinal muscular atrophy (SMA). SMN2 is …
and SMN2. Homozygous loss of SMN1 causes spinal muscular atrophy (SMA). SMN2 is …
General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer.
Q Sun, A Mayeda, RK Hampson… - Genes & …, 1993 - genesdev.cshlp.org
The general splicing factor SF2/ASF binds in a sequence-specific manner to a purine-rich
exonic splicing enhancer (ESE) in the last exon of bovine growth hormone (bGH) pre …
exonic splicing enhancer (ESE) in the last exon of bovine growth hormone (bGH) pre …
A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a …
M Ashiya, PJ Grabowski - Rna, 1997 - rnajournal.cshlp.org
Tissue-and stage-specific alternative splicing events are widespread in mammals, yet the
factors and mechanisms that direct these important posttranscriptional events are poorly …
factors and mechanisms that direct these important posttranscriptional events are poorly …
Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat β-tropomyosin gene
CD Chen, R Kobayashi, DM Helfman - Genes & development, 1999 - genesdev.cshlp.org
In the rat β-tropomyosin (β-TM) gene, exons 6 and 7 are spliced alternatively in a mutually
exclusive manner. Exon 6 is included in mRNA encoding nonmuscle TM-1, whereas exon 7 …
exclusive manner. Exon 6 is included in mRNA encoding nonmuscle TM-1, whereas exon 7 …