Recent advances in the chemistry of 1, 2, 4-triazoles: Synthesis, reactivity and biological activities
Triazoles are important heterocyclic motifs that are widely found in molecular architectures
with medicinal and pharmaceutical properties. Considering the importance of these …
with medicinal and pharmaceutical properties. Considering the importance of these …
p53 as a potential target for treatment of cancer: A perspective on recent advancements in small molecules with structural insights and SAR studies
Cancer represents one of the world's biggest hazardous diseases. p53 is the uttermost
researched tumour suppressor protein. It is commonly considered the “guardian of the …
researched tumour suppressor protein. It is commonly considered the “guardian of the …
Design and synthesis of new triarylimidazole derivatives as dual inhibitors of BRAFV600E/p38α with potential antiproliferative activity
Recent studies have shown that combining kinase inhibitors has additive and synergistic
effects. BRAF V600E and p38α have been extensively studied as potential therapeutic …
effects. BRAF V600E and p38α have been extensively studied as potential therapeutic …
[HTML][HTML] New Schiff bases derived from dimethylpyridine-1, 2, 4-triazole hybrid as cytotoxic agents targeting gastrointestinal cancers: Design, synthesis, biological …
M Strzelecka, B Wiatrak, P Jawień, Ż Czyżnikowska… - Bioorganic …, 2023 - Elsevier
In this research, a series of novel hybrid structures of dimethylpyridine-1, 2, 4-triazole Schiff
bases were designed, synthesized, and evaluated for their in vitro cytotoxic potency on …
bases were designed, synthesized, and evaluated for their in vitro cytotoxic potency on …
Design, synthesis and evaluation of novel 1, 2, 4-triazole derivatives as promising anticancer agents
Herein, we reported the synthesis of nineteen novel 1, 2, 4-triazole derivatives including 1, 3-
diphenyl-2-(1H-1, 2, 4-triazol-1-yl) propan-1-ones (7a-e), 1-(1, 3-diphenylpropan-2-yl)-1 H-1 …
diphenyl-2-(1H-1, 2, 4-triazol-1-yl) propan-1-ones (7a-e), 1-(1, 3-diphenylpropan-2-yl)-1 H-1 …
Synthesis and biological evaluation of indole-2-carboxamides with potent apoptotic antiproliferative activity as egfr/cdk2 dual inhibitors
LH Al-Wahaibi, YA Mostafa, MH Abdelrahman… - Pharmaceuticals, 2022 - mdpi.com
The apoptotic antiproliferative actions of our previously reported CB1 allosteric modulators 5-
chlorobenzofuran-2-carboxamide derivatives VIIa–j prompted us to develop and synthesise …
chlorobenzofuran-2-carboxamide derivatives VIIa–j prompted us to develop and synthesise …
Design, synthesis, and biological evaluation of indole-2-carboxamides as potential multi-target antiproliferative agents
LH Al-Wahaibi, AF Mohammed, MH Abdelrahman… - Pharmaceuticals, 2023 - mdpi.com
A small set of indole-based derivatives, IV and Va–I, was designed and synthesized.
Compounds Va–i demonstrated promising antiproliferative activity, with GI50 values ranging …
Compounds Va–i demonstrated promising antiproliferative activity, with GI50 values ranging …
Discovery of new cyanopyridine/chalcone hybrids as dual inhibitors of EGFR/BRAFV600E with promising antiproliferative properties
As dual EGFR and BRAFV600E inhibitors, 2‐(3‐cyano‐4, 6‐bis (aryl)‐2‐oxo‐1, 2‐
dihydropyridine‐1‐yl)‐N‐(4‐cinnamoylphenyl) acetamide derivatives 8–20 were developed …
dihydropyridine‐1‐yl)‐N‐(4‐cinnamoylphenyl) acetamide derivatives 8–20 were developed …
Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAFV600E Inhibitors
Some new Bis-pyrazoline hybrids 8–17 with dual EGFR and BRAFV600E inhibitors have
been developed. The target compounds were synthesized and tested in vitro against four …
been developed. The target compounds were synthesized and tested in vitro against four …
New Fluoroquinolone‐1,2,4‐triazoles as Potent Antibacterial Agents: Design, Synthesis, Docking Studies and in Silico ADME Profiles
V Rao Gollapalli, H Babu Bollikolla… - Chemistry & …, 2023 - Wiley Online Library
Our current work is aimed at synthesizing novel substituted 1, 2, 4‐triazolyl‐fluoroquinolone
analogs and study of their biological activity to find active promising molecules. The …
analogs and study of their biological activity to find active promising molecules. The …