Clonal hematopoiesis and nonhematologic disorders
S Jaiswal - Blood, The Journal of the American Society of …, 2020 - ashpublications.org
Clonal expansions of mutated hematopoietic cells, termed clonal hematopoiesis, are
common in aging humans. One expected consequence of mutation-associated clonal …
common in aging humans. One expected consequence of mutation-associated clonal …
Therapy-related myeloid neoplasms: when genetics and environment collide
ME McNerney, LA Godley, MM Le Beau - Nature Reviews Cancer, 2017 - nature.com
Therapy-related myeloid neoplasms (t-MN) arise as a late effect of chemotherapy and/or
radiation administered for a primary condition, typically a malignant disease, solid organ …
radiation administered for a primary condition, typically a malignant disease, solid organ …
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection
Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to
infectious disease risk are incompletely understood. Age-related mosaic chromosomal …
infectious disease risk are incompletely understood. Age-related mosaic chromosomal …
Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations
The selective pressures that shape clonal evolution in healthy individuals are largely
unknown. Here we investigate 8,342 mosaic chromosomal alterations, from 50 kb to 249 Mb …
unknown. Here we investigate 8,342 mosaic chromosomal alterations, from 50 kb to 249 Mb …
Genetic predisposition to mosaic Y chromosome loss in blood
Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common
form of clonal mosaicism,,,–, yet our knowledge of the causes and consequences of this is …
form of clonal mosaicism,,,–, yet our knowledge of the causes and consequences of this is …
[HTML][HTML] The spectrum of sex differences in cancer
JB Rubin - Trends in cancer, 2022 - cell.com
Sex differences in cellular and systems biology have been evolutionarily selected to
optimize reproductive success in all species with little (sperm) and big (ova) gamete …
optimize reproductive success in all species with little (sperm) and big (ova) gamete …
Mosaicism in health and disease—clones picking up speed
Post-zygotic variation refers to genetic changes that arise in the soma of an individual and
that are not usually inherited by the next generation. Although there is a paucity of research …
that are not usually inherited by the next generation. Although there is a paucity of research …
Chromosomal alterations among age-related haematopoietic clones in Japan
The extent to which the biology of oncogenesis and ageing are shaped by factors that
distinguish human populations is unknown. Haematopoietic clones with acquired mutations …
distinguish human populations is unknown. Haematopoietic clones with acquired mutations …
Germline risk of clonal haematopoiesis
Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …
somatic mutations that is associated with an increased risk of haematological malignancies …
Monogenic and polygenic inheritance become instruments for clonal selection
Clonally expanded blood cells that contain somatic mutations (clonal haematopoiesis) are
commonly acquired with age and increase the risk of blood cancer,,,,,,,–. The blood clones …
commonly acquired with age and increase the risk of blood cancer,,,,,,,–. The blood clones …