COVID-19 vaccine: A recent update in pipeline vaccines, their design and development strategies
Coronavirus Disease 2019 named as COVID-19 imposing a huge burden on public health
as well as global economies, is caused by a new strain of betacoronavirus named as SARS …
as well as global economies, is caused by a new strain of betacoronavirus named as SARS …
[HTML][HTML] Artificial intelligence for COVID-19 drug discovery and vaccine development
SARS-COV-2 has roused the scientific community with a call to action to combat the growing
pandemic. At the time of this writing, there are as yet no novel antiviral agents or approved …
pandemic. At the time of this writing, there are as yet no novel antiviral agents or approved …
[HTML][HTML] A review on the recent advances and application of vaccines against fish pathogens in aquaculture
Globally, aquaculture has faced serious economic problems due to bacterial, viral, and
various other infectious diseases of different origins. Even though such diseases are being …
various other infectious diseases of different origins. Even though such diseases are being …
Disease manifestations and pathogenic mechanisms of group A Streptococcus
MJ Walker, TC Barnett, JD McArthur… - Clinical microbiology …, 2014 - Am Soc Microbiol
Streptococcus pyogenes, also known as group A Streptococcus (GAS), causes mild human
infections such as pharyngitis and impetigo and serious infections such as necrotizing …
infections such as pharyngitis and impetigo and serious infections such as necrotizing …
Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?
Hosts and bacteria have coevolved over millions of years, during which pathogenic bacteria
have modified their virulence mechanisms to adapt to host defense systems. Although the …
have modified their virulence mechanisms to adapt to host defense systems. Although the …
Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design
R Rappuoli, MJ Bottomley, U D'Oro, O Finco… - Journal of Experimental …, 2016 - rupress.org
Traditionally, vaccines have been developed by cultivating infectious agents and isolating
the inactivated whole pathogen or some of its purified components. 20 years ago, reverse …
the inactivated whole pathogen or some of its purified components. 20 years ago, reverse …
[HTML][HTML] Designing a novel multi-epitope vaccine to evoke a robust immune response against pathogenic multidrug-resistant Enterococcus faecium bacterium
Enterococcus faecium is an emerging ESKAPE bacterium that is capable of causing severe
public health complications in humans. There are currently no licensed treatments or …
public health complications in humans. There are currently no licensed treatments or …
Vaccines for the 21st century
I Delany, R Rappuoli, E De Gregorio - EMBO molecular medicine, 2014 - embopress.org
In the last century, vaccination has been the most effective medical intervention to reduce
death and morbidity caused by infectious diseases. It is believed that vaccines save at least …
death and morbidity caused by infectious diseases. It is believed that vaccines save at least …
Staphylococcus aureus biofilms: Properties, regulation, and roles in human disease
NK Archer, MJ Mazaitis, JW Costerton, JG Leid… - Virulence, 2011 - Taylor & Francis
Increasing attention has been focused on understanding bacterial biofilms and this growth
modality's relation to human disease. In this review we explore the genetic regulation and …
modality's relation to human disease. In this review we explore the genetic regulation and …
[HTML][HTML] Changing priorities in vaccinology: antibiotic resistance moving to the top
A Tagliabue, R Rappuoli - Frontiers in immunology, 2018 - frontiersin.org
Antimicrobial resistance (AMR) is currently the most alarming issue for human health. AMR
already causes 700,000 deaths/year. It is estimated that 10 million deaths due to AMR will …
already causes 700,000 deaths/year. It is estimated that 10 million deaths due to AMR will …