Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics

R Tenchov, JM Sasso, X Wang, WS Liaw, CA Chen… - ACS …, 2022 - ACS Publications
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …

Therapeutic and diagnostic translation of extracellular vesicles in cardiovascular diseases: roadmap to the clinic

S Sahoo, M Adamiak, P Mathiyalagan, F Kenneweg… - Circulation, 2021 - Am Heart Assoc
Exosomes are small membrane-bound vesicles of endocytic origin that are actively
secreted. The potential of exosomes as effective communicators of biological signaling in …

Atorvastatin enhances the therapeutic efficacy of mesenchymal stem cells-derived exosomes in acute myocardial infarction via up-regulating long non-coding RNA …

P Huang, L Wang, Q Li, X Tian, J Xu, J Xu… - Cardiovascular …, 2020 - academic.oup.com
Aims Naturally secreted nanovesicles, known as exosomes, play important roles in stem cell-
mediated cardioprotection. We have previously demonstrated that atorvastatin (ATV) …

[HTML][HTML] The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets

M Ghafourian, R Mahdavi, Z Akbari Jonoush… - Cell Communication and …, 2022 - Springer
Extracellular vehicles (EVs) are a heterogeneous group of cell and membranous particles
originating from different cell compartments. EVs participate in many essential physiological …

[HTML][HTML] Combinatorial treatment of acute myocardial infarction using stem cells and their derived exosomes resulted in improved heart performance

P Huang, L Wang, Q Li, J Xu, J Xu, Y Xiong… - Stem cell research & …, 2019 - Springer
Background Bone marrow mesenchymal stem cells (MSCs) are among the most common
cell types to be used and studied for cardiac regeneration. Low survival rate and difficult …

[HTML][HTML] Exosome in cardiovascular diseases: a complex world full of hope

G Bellin, C Gardin, L Ferroni, JC Chachques… - Cells, 2019 - mdpi.com
Exosomes are a subgroup of extracellular vesicles containing a huge number of bioactive
molecules. They represent an important means of cell communication, mostly between …

Advances in injectable hydrogel strategies for heart failure treatment

S He, Z Zhang, R Luo, Q Jiang, L Yang… - Advanced Healthcare …, 2023 - Wiley Online Library
Heart failure (HF) affects 60 million people worldwide and has developed into a global
public health problem surpassing cancer and urgently needs to be solved. According to the …

[HTML][HTML] Adipose tissue stem cells in regenerative medicine

VV Miana, EAP González - Ecancermedicalscience, 2018 - ncbi.nlm.nih.gov
Adipose tissue-derived stem cells (ADSCs) are mesenchymal cells with the capacity for self-
renewal and multipotential differentiation. This multipotentiality allows them to become …

[HTML][HTML] Extracellular vesicles in cardiovascular diseases: alternative biomarker sources, therapeutic agents, and drug delivery carriers

SY Chong, CK Lee, C Huang, YH Ou… - International journal of …, 2019 - mdpi.com
Cardiovascular diseases (CVD) represent the leading cause of morbidity and mortality
globally. The emerging role of extracellular vesicles (EVs) in intercellular communication …

[HTML][HTML] Exosomes in myocardial repair: advances and challenges in the development of next-generation therapeutics

M Adamiak, S Sahoo - Molecular Therapy, 2018 - cell.com
Myocardial disease is a leading cause of morbidity and mortality worldwide. Given the
limited regenerative capacity of the human heart following myocardial injury, stem cell …