Genome-wide association studies have discovered numerous genomic loci associated with
Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. We …

Regulation of transcript structure generates transcript diversity and plays an important role in
human disease,,,,,–. The advent of long-read sequencing technologies offers the opportunity …

Regulatory variants are often context specific, modulating gene expression in a subset of
possible cellular states. Although these genetic effects can play important roles in disease …

The eQTL Catalogue is an open database of uniformly processed human molecular
quantitative trait loci (QTLs). We are continuously updating the resource to further increase …

Many plants are able to regenerate upon cutting, and this process can be enhanced in vitro
by incubating explants on hormone-supplemented media. While such protocols have been …

Genetic variants regulating RNA splicing and transcript usage have been implicated in both
common and rare diseases. Although transcript usage quantitative trait loci (tuQTLs) have …

The recount2 resource is composed of over 70,000 uniformly processed human RNA-seq
samples spanning TCGA and SRA, including GTEx. The processed data can be accessed …

Identifying cellular functions dysregulated by disease-associated variants could implicate
novel pathways for drug targeting or modulation in cell therapies. However, follow-up …

Understanding the cellular mechanisms behind diabetes-related cardiomyopathy is crucial
as it is a common and deadly complication of diabetes mellitus. Dysregulation of the …

Extranuclear localization of long non-coding RNAs (lncRNAs) is poorly understood. Based
on machine learning evaluations, we propose a lncRNA-mitochondrial interaction pathway …