Endothelial dysfunction and immunothrombosis in sepsis

E Maneta, E Aivalioti, S Tual-Chalot… - Frontiers in …, 2023 - frontiersin.org
Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …

The immune nature of platelets revisited

A Maouia, J Rebetz, R Kapur, JW Semple - Transfusion medicine reviews, 2020 - Elsevier
Platelets are the primary cellular mediators of hemostasis and this function firmly acquaints
them with a variety of inflammatory processes. For example, platelets can act as circulating …

Platelets in sepsis: an update on experimental models and clinical data

A Assinger, WC Schrottmaier, M Salzmann… - Frontiers in …, 2019 - frontiersin.org
Beyond their important role in hemostasis, platelets play a crucial role in inflammatory
diseases. This becomes apparent during sepsis, where platelet count and activation …

Platelets at the interface of thrombosis, inflammation, and cancer

AT Franco, A Corken, J Ware - Blood, The Journal of the …, 2015 - ashpublications.org
Although once primarily recognized for its roles in hemostasis and thrombosis, the platelet
has been increasingly recognized as a multipurpose cell. Indeed, circulating platelets have …

Mouse and human FcR effector functions

P Bruhns, F Jönsson - Immunological reviews, 2015 - Wiley Online Library
Mouse and human FcRs have been a major focus of attention not only of the scientific
community, through the cloning and characterization of novel receptors, and of the medical …

Platelets and infection–an emerging role of platelets in viral infection

A Assinger - Frontiers in immunology, 2014 - frontiersin.org
Platelets are anucleate blood cells that play a crucial role in the maintenance of hemostasis.
While platelet activation and elevated platelet counts (thrombocytosis) are associated with …

Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration

N Cloutier, I Allaeys, G Marcoux… - Proceedings of the …, 2018 - National Acad Sciences
There is a growing appreciation for the contribution of platelets to immunity; however, our
knowledge mostly relies on platelet functions associated with vascular injury and the …

The role of platelets in sepsis

SF de Stoppelaar, C van't Veer… - Thrombosis and …, 2014 - thieme-connect.com
Platelets are small circulating anucleate cells that are of crucial importance in haemostasis.
Over the last decade, it has become increasingly clear that platelets play an important role in …

Platelet signaling and disease: targeted therapy for thrombosis and other related diseases

J Yeung, W Li, M Holinstat - Pharmacological reviews, 2018 - ASPET
Platelets are essential for clotting in the blood and maintenance of normal hemostasis.
Under pathologic conditions such as atherosclerosis, vascular injury often results in …

The platelet response to tissue injury

F Eisinger, J Patzelt, HF Langer - Frontiers in medicine, 2018 - frontiersin.org
In recent years, various studies have increasingly explained platelet functions not only in
their central role as a regulator in cellular hemostasis and coagulation. In fact, there is …