GABAA receptor: Positive and negative allosteric modulators
RW Olsen - Neuropharmacology, 2018 - Elsevier
Abstract gamma-Aminobutyric acid (GABA)-mediated inhibitory neurotransmission and the
gene products involved were discovered during the mid-twentieth century. Historically …
gene products involved were discovered during the mid-twentieth century. Historically …
International Union of Basic and Clinical Pharmacology. CVI: GABAA receptor subtype-and function-selective ligands: key issues in translation to humans
W Sieghart, MM Savić - Pharmacological reviews, 2018 - ASPET
GABAA receptors are the major inhibitory transmitter receptors in the brain. They are ligand-
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …
International Union of Pharmacology. LXX. Subtypes of γ-aminobutyric acidA receptors: classification on the basis of subunit composition, pharmacology, and function …
RW Olsen, W Sieghart - Pharmacological reviews, 2008 - ASPET
In this review we attempt to summarize experimental evidence on the existence of defined
native GABAA receptor subtypes and to produce a list of receptors that actually seem to exist …
native GABAA receptor subtypes and to produce a list of receptors that actually seem to exist …
How addictive drugs disrupt presynaptic dopamine neurotransmission
D Sulzer - Neuron, 2011 - cell.com
The fundamental principle that unites addictive drugs appears to be that each enhances
synaptic dopamine by means that dissociate it from normal behavioral control, so that they …
synaptic dopamine by means that dissociate it from normal behavioral control, so that they …
Neuroactive steroids
SM Paul, RH Purdy - The FASEB Journal, 1992 - Wiley Online Library
Neuroactive steroids are natural or synthetic steroids that rapidly alter the excitability of
neurons by binding to membrane‐bound receptors such as those for inhibitory and (or) …
neurons by binding to membrane‐bound receptors such as those for inhibitory and (or) …
GABAA‐receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits
JM Fritschy, H Mohler - Journal of Comparative Neurology, 1995 - Wiley Online Library
GABAA‐receptors display an extensive structural heterogeneity based on the differential
assembly of a family of at least 15 subunits (α1–6, β1–3, γ1–3, θ, ρl–2) into distinct …
assembly of a family of at least 15 subunits (α1–6, β1–3, γ1–3, θ, ρl–2) into distinct …
Regulation of the acute production of steroids in steroidogenic cells
Introduction The steroid hormones constitute a very important class of compounds and are
present in most species. The hormones that are synthesized in the adrenal gland, namely …
present in most species. The hormones that are synthesized in the adrenal gland, namely …
GABA: an excitatory transmitter in early postnatal life
It inhibits neuronal firing by increasing a Cl-conductance. Bicuculline blocks this effect and
induces interictal discharges. A different picture is present in neonatal hippocampal …
induces interictal discharges. A different picture is present in neonatal hippocampal …
Which GABAA-receptor subtypes really occur in the brain?
RM McKernan, PJ Whiting - Trends in neurosciences, 1996 - cell.com
GABA A receptors are a heterogeneous family of ligand-gated ion channels responsible for
mediating inhibitory neurotransmission in the CNS. Since the identification of mammalian …
mediating inhibitory neurotransmission in the CNS. Since the identification of mammalian …
Effects of moderate alcohol consumption on the central nervous system
MJ Eckardt, SE File, GL Gessa, KA Grant… - Alcoholism: Clinical …, 1998 - Wiley Online Library
The concept of moderate consumption of ethanol (beverage alcohol) has evolved over time
from considering this level of intake to be nonintoxicating and noninjurious, to …
from considering this level of intake to be nonintoxicating and noninjurious, to …