Abstract Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …

Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Background Antimicrobial resistance (AMR) poses an important global health challenge in
the 21st century. A previous study has quantified the global and regional burden of AMR for …

Background Antimicrobial resistance (AMR) poses a major threat to human health around
the world. Previous publications have estimated the effect of AMR on incidence, deaths …

Background Sepsis is life-threatening organ dysfunction due to a dysregulated host
response to infection. It is considered a major cause of health loss, but data for the global …

Background Early reports indicate that AKI is common among patients with coronavirus
disease 2019 (COVID-19) and associated with worse outcomes. However, AKI among …

Purpose To investigate the global burden of sepsis in hospitalized adults by updating and
expanding a systematic review and meta-analysis and to compare findings with recent …

Importance Sepsis is a heterogeneous syndrome. Identification of distinct clinical
phenotypes may allow more precise therapy and improve care. Objective To derive sepsis …

Purpose Sepsis is recognized as a global public health problem, but the proportion due to
hospital-acquired infections remains unclear. We aimed to summarize the epidemiological …

Sepsis is a common condition that is associated with unacceptably high mortality and, for
many of those who survive, long-term morbidity. Increased awareness of the condition …