Free radical pathways play a major role in the degradation of protein pharmaceuticals.
Inspired by biochemical reactions carried out by thiyl radicals in various enzymatic …

We have developed an Escherichia coli strain for the in vivo production of O-glycosylated
proteins. This was achieved using a dual plasmid approach: one encoding a therapeutic …

Growth hormone (GH) structure is stabilised by two disulphide bonds, C53-C165 and C182-
C189 in human GH. Researchers have investigatedthe role of these structural features since …

Human growth hormone (hGH) plays an important role in growth control, growth promotion,
cell development, and regulation of numerous metabolic pathways in the human body and …

Disulfide bonds stabilize proteins by cross‐linking distant regions into a compact three‐
dimensional structure. They can also participate in hydrolytic and oxidative pathways to form …

Purpose Thiol-disulfide exchange was monitored in recombinant human growth hormone
(hGH) and in model tryptic peptides derived from hGH to investigate the effects of higher …

In this review, we will analyze the family of growth hormone (GH) genes, the territories where
they are produced, the proteolytic generation of GH isoforms, both at the pituitary and tissue …

Recombinant human growth hormone (rhGH) and GH receptor antagonists (GHAs) are used
clinically to treat a range of disorders associated with GH deficiency or hypersecretion …

Tetrahymena thermophila ökaryotik, silli ve tek hücreli bir organizma olup, kısa bölünme
süresi ve kolay kültürizasyona sahip bir model organizmadır. Organizmanın rekombinant …