Toxicity of nanoparticles in biomedical application: nanotoxicology

C Egbuna, VK Parmar, J Jeevanandam… - Journal of …, 2021 - Wiley Online Library
Nanoparticles are of great importance in development and research because of their
application in industries and biomedicine. The development of nanoparticles requires …

[HTML][HTML] Challenges and opportunities to penetrate the blood-brain barrier for brain cancer therapy

DH Upton, C Ung, SM George, M Tsoli, M Kavallaris… - Theranostics, 2022 - ncbi.nlm.nih.gov
Despite significant advances in research, the prognosis for both primary and secondary
brain cancers remains poor. The blood-brain barrier (BBB) is a complex and unique semi …

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

DB Vieira, LF Gamarra - International journal of nanomedicine, 2016 - Taylor & Francis
This review summarizes articles that have been reported in literature on liposome-based
strategies for effective drug delivery across the blood–brain barrier. Due to their unique …

Overcoming the blood–brain tumor barrier for effective glioblastoma treatment

O Van Tellingen, B Yetkin-Arik, MC De Gooijer… - Drug Resistance …, 2015 - Elsevier
Gliomas are the most common primary brain tumors. Particularly in adult patients, the vast
majority of gliomas belongs to the heterogeneous group of diffuse gliomas, ie. glial tumors …

Neurotoxicity of nanomaterials: An up-to-date overview

DM Teleanu, C Chircov, AM Grumezescu, RI Teleanu - Nanomaterials, 2019 - mdpi.com
The field of nanotechnology, through which nanomaterials are designed, characterized,
produced, and applied, is rapidly emerging in various fields, including energy, electronics …

Nanogels as novel nanocarrier systems for efficient delivery of CNS therapeutics

Y Zhang, Z Zou, S Liu, S Miao, H Liu - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Nanogels have come out as a great potential drug delivery platform due to its prominently
high colloidal stability, high drug loading, core-shell structure, good permeation property and …

Extracellular vesicles for the treatment of central nervous system diseases

V Gratpain, A Mwema, Y Labrak, GG Muccioli… - Advanced drug delivery …, 2021 - Elsevier
The interest in extracellular vesicles (EVs) increased during the last decade. It is now
established that these vesicles play a role in the pathogenesis of central nervous system …

Nanoparticles: A Hope for the Treatment of Inflammation in CNS

FD Zhu, YJ Hu, L Yu, XG Zhou, JM Wu… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammation, an inflammatory response within the central nervous system (CNS), is a
main hallmark of common neurodegenerative diseases, including Alzheimer's disease (AD) …

Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats

C Zhang, EA Nance, P Mastorakos, J Chisholm… - Journal of Controlled …, 2017 - Elsevier
Glioblastoma multiforme (GBM) is highly invasive and uniformly fatal, with median survival<
20 months after diagnosis even with the most aggressive treatment that includes surgery …

MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound

KF Timbie, U Afzal, A Date, C Zhang, J Song… - Journal of Controlled …, 2017 - Elsevier
Systemically administered chemotherapeutic drugs are often ineffective in the treatment of
invasive brain tumors due to poor therapeutic index. Within gliomas, despite the presence of …