Allosteric regulatory processes are implicated at all levels of biological function. Recent
advances in our understanding of the diverse and functionally significant class of intrinsically …

Highlights•Cryo-EM structures of Escherichia coli DNA polymerase III complexes.•Bacterial
polymerases quickly exchange at replication forks.•Bacterial replisomes can work in a …

The associative memory, water-mediated, structure and energy model (AWSEM) has been
successfully used to study protein folding, binding, and aggregation problems. In this work …

The binding of transcription factors (TFs) to DNA controls most aspects of cellular function,
making the understanding of their binding kinetics imperative. The standard description of …

Single-stranded DNA-binding proteins (SSBs) support DNA replication by protecting single-
stranded DNA from nucleolytic attack, preventing intra-strand pairing events and playing …

Accurate transcription of genetic information is crucial, involving precise recognition of the
binding motifs by DNA-binding proteins. While some proteins rely on short-range …

The accurate reading of genetic information during transcription is essential for the
expression of genes. Sequence binding specificity very often is attributed to short-range …

Conspectus Dynamic protein–DNA interactions constitute highly robust cellular machineries
to fulfill cellular functions. A vast number of studies have focused on how DNA-binding …

Small-angle X-ray scattering (SAXS) experiments provide valuable structural data for
biomolecules in solution. We develop a highly efficient maximum entropy approach to fit …

Linker histone H1 is an essential regulatory protein for many critical biological processes,
such as eukaryotic chromatin packaging and gene expression. Mis-regulation of H1s is …