The mammalian hematopoietic system is remarkably efficient in meeting an organism's vital
needs, yet is highly sensitive and exquisitely regulated. Much of the organismal control over …

Germline genetic defects impairing telomere length maintenance may result in severe
medical conditions in humans, from aplastic anemia and myeloid neoplasms to interstitial …

Telomere shortening is a hallmark of aging and is counteracted by telomerase. As in
humans, the zebrafish gut is one of the organs with the fastest rate of telomere decline …

Androgens have been reported to elongate telomeres in retrospective and prospective trials
with patients with telomeropathies, mainly with bone marrow failure. In our single-arm …

Telomerase activity is essential for the self-renewal and potential of embryonic, induced
pluripotent, and cancer stem cells, as well as a few somatic stem cells, such as human urine …

Telomere biology disorders (TBDs), caused by pathogenic germ line variants in telomere-
related genes, present with multiorgan disease and a predisposition to cancer. Clonal …

SF3B1 mutations, which occur in 20% of patients with myelodysplastic syndromes (MDS),
are the hallmarks of a specific MDS subtype, MDS with ringed sideroblasts (MDS-RS), which …

Mechanistic studies of immune bone marrow failure are difficult because of the scarcity of
residual cells, the involvement of multiple cell types, and the inherent complexities of …

Hematopoietic stem cells (HSCs) exhibit significant functional and metabolic alterations
within the lung cancer microenvironment, contributing to tumor progression and immune …

The telomerase RNA component (TERC) gene plays an important role in telomerase-
dependent extension and maintenance of the telomeres. In the event of TERC …