For eradication of tuberculosis (TB) by 2050, the declared aim of the Stop TB Partnership,
novel treatment strategies are indispensable. The emerging epidemic of multi-drug resistant …

Tuberculosis (TB) is now among the top ten causes of mortality worldwide being resulted in
1.7 million deaths including 0.4 million among people with HIV in 2016. The Bacille …

Very substantial efforts have been made over the past decade or more to develop vaccines
against tuberculosis. Historically, this began with a view to replace the current vaccine …

The prophylactic capacity of the RUTI® vaccine, based on fragmented cells of
Mycobacterium tuberculosis, has been evaluated in respect to aerosol challenge with …

Development of vaccines for infectious diseases has come a long way with recent
advancements in adjuvant developments and discovery of new antigens that are capable of …

Objectives The objective of this study was to evaluate the safety and efficacy of the
therapeutic vaccine RUTI® with or without the standard of care (SOC) chemotherapy for TB …

This chapter explores tuberculosis (TB) vaccine design, formulation, preparation, and
manufacture; beginning with the first preparations of bacillus Calmette–Guérin (BCG) …

Currently, over one-third of the global population is infected with tuberculosis (TB), one of
the world's most deadly infectious diseases. The current vaccine against TB, Bacille …

RUTI R vaccine is composed of fragmented, heat-killed M. tuberculosis cells grown under
hypoxic conditions designed to shorten tuberculosis treatment. It has proven to be clinically …

This thesis employs a variety of tools to generate and evaluate an innovative tuberculosis
(TB) vaccine candidate, to help improve the diagnostic algorithm for multidrug-resistant …