Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Oxidative stress resulting from the accumulation of high levels of reactive oxygen species is
a salient feature of, and a well-recognised pathological factor for, diverse pathologies. One …

Transcriptional regulation of circadian rhythms is essential for lipid metabolic homeostasis,
disruptions of which can lead to metabolic diseases. Whether N 6-methyladenosine (m 6 A) …

Traditional drugs or therapies rarely have effects on regression of chronic liver diseases,
which result in many cases from sustained oxidative stress. In recent years, ellagic acid (EA) …

Oxidative stress is a key pathological feature implicated in both acute and chronic liver
diseases, including drug‐induced liver injury (DILI). The latter describes hepatic injury …

A complex network of many interacting mechanisms orchestrates immune and inflammatory
responses. Among these, the cation channels of the transient receptor potential (TRP) family …

Acetaminophen (APAP) was first synthesized in the 1800s, and came on the market
approximately 65 years ago. Since then, it has become one of the most used drugs in the …

Abstract Licochalcone A (Lico A), isolated from Xinjiang licorice Glycyrrhiza inflate, has been
shown to have antioxidative potential via the activation of nuclear factor-erythroid 2-related …

Introduction The purpose of this review was to discuss new issues related to safety, labeling,
dosing, and a better understanding of the analgesic effect of acetaminophen. Methods The …

Background: Cisplatin is a widely used anti-tumor agent but its use is frequently limited by
nephrotoxicity. Transient receptor potential melastatin 2 (TRPM2) is a non-selective cation …