Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

The objective of this review is to provide a comprehensive summary of the latest
methodological advancements and emerging patterns in utilizing lipidomics in clinical …

Background Prognostication is very important to clinicians and families during the early
management of severe traumatic brain injury (sTBI), however, there are no gold standard …

Traumatic brain injury (TBI) affects millions of people of all ages around the globe. TBI is
notoriously hard to diagnose at the point of care, resulting in incorrect patient management …

Introduction The hunt for new biomarkers–for the diagnosis of subcategories of disease, or
for the monitoring of the efficacy of novel therapeutics–is an increasingly relevant challenge …

Mild traumatic brain injury (mTBI) accounts for 70–90% of all TBI cases. Lipid metabolites
have important roles in plasma membrane biogenesis, function, and cell signaling. As TBI …

Metabolomics is a fast-developing technique used in biomedical researches focusing on
pathological mechanism illustration or novel biomarker development for diseases. The …

Prognostication is challenging in patients with traumatic brain injury (TBI) in whom computed
tomography (CT) fails to fully explain a low level of consciousness. Serum biomarkers reflect …

Lipidomic alterations have been associated with various neurological diseases. Examining
temporal changes in serum lipidomic profiles, irrespective of injury type, reveals promising …